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The causes of schizophrenia remain a subject of scientific debate. Researchers associate the disease with a combination of genetic mutations, social conditions, and external influences. The famous psychiatrist Ronald Laing called it a natural reaction to the absurdity of the modern world. However, the exact mechanisms triggering destructive changes in the psyche have not yetRead More

Phencyclidine (PCP, “angel dust”) is a synthetic dissociative drug originally developed as an anesthetic, but banned due to severe side effects. The drug causes distortion of perception, hallucinations, a feeling of detachment from one’s own body, and aggressive behavior. History and distribution Phencyclidine was first synthesized in 1956 as an intravenous anesthetic. Initially, it wasRead More

Kratom has gained popularity as a legal remedy, a “natural” and readily available alternative to prescription analgesics and synthetic psychoactive substances. It was originally used in Asian countries, but globalization has helped spread this semi-legal “semi-medicine” to the West. Kratom has a specific feature: in small doses it acts as a stimulant, but in largeRead More

These substances produce a wide variety of diverse effects, which include sedation, drowsiness, decreased anxiety, skeletal muscle relaxation, amnesia (forgetting situations from the administration of a substance) and anticonvulsant activity. Despite the fact that all benzodiazepines (BDZ) have similar effects, there are differences in the selectivity with which each of them causes some of theRead More

Methoxetamine, abbreviated MXE, is a dissociative hallucinogen marketed as a designer drug. It differs from many dissociatives such as ketamine and phencyclidine (PCP), which were developed as pharmaceuticals for use as general anesthetics, in that it was developed for distribution in the gray market. Due to its structural similarity to ketamine, it is no longerRead More

The European Narcotics Agency (EUDA.) presented yesterday in Lisbon the 30th Report on Drugs 2025: Trends and Developments, which warns of an increase in the number of synthetic substances such as cathinones, nitazenes and cannabis products synthetic or with the addition of semi-synthetic cannabinoids. Given this increase in the supply and demand for synthetic cannabinoidsRead More

Pain, a universal human reaction, often requires relief that does not worsen well-being with side effects. Traditional opioids, while effective, carry with them many risks. However, scientists have recently created an alternative that does not have such flaws. This is what Duke University writes about. SBI-810 is an experimental drug developed by researchers at DukeRead More

Benzodiazepines – a list of drugs and their effects. What to do in case of poisoning and intoxication? What is the most effective antidote? We will talk about the narcotic effect of benzodiazepines, as well as analyze the mechanism of action of the drugs. ak is a group of psychotropic drugs that have sedative, sedative,Read More

Nootropics are neurometabolic stimulants that have a positive effect on complexly organized psychophysiological processes. The mechanism of their action is associated with the restoration of the bioenergetic and metabolic functions of the neuron, as well as the neurotransmitter systems of the brain. The principle of operation of nootropic drugs, as their name implies, is aimedRead More

Anandamide (arachidonethanolamine) is an endogenous neuropeptide that specifically interacts with cannabinoid receptors in the brain. He was also distinguished in 1992 at the Hebrew University in Jerusalem. The name comes from the Sanskrit word “ananda” — bliss. Effects: Anandamide acts on CB1 cannabinoid receptors in the central nervous system and CB2 cannabinoid receptors in theRead More