Bretazenil
$24.00
Bretazenil (Ro16-6028) is an imidazopyrrolobenzodiazepine anxiolytic drug of the benzodiazepine class. It was first synthesized in 1988 as a highly potent benzodiazepine that causes less addiction with a reduced profile of side effects, causes less strong development of tolerance…
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$8.50 (per gram) |
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Description
Bretazenil (Ro16-6028) is an imidazopyrrolobenzodiazepine anxiolytic drug of the benzodiazepine class. It was first synthesized in 1988 as a highly potent benzodiazepine that causes less addiction with a reduced profile of side effects, causes less strong development of tolerance. Structurally, bretazenil is close to the GABA antagonist flumazenil, although it has a different effect. It differs from traditional 1,4-benzodiazepines in that it is a partial agonist and binds to α1, α2, α3, α4, α5 and α6 subunits containing benzodiazepine GABA receptor complexes. 0.5 bretazenil is equivalent to 10 mg of diazepam, but has a stronger sedative effect.
Studies on primates have shown that bretazenil enhances the action of neurosteroids acting on the binding site of neurosteroids of the GABA receptor. Bretazenil causes a decrease in cortisol secretion and significantly increases the release of prolactin, has hypnotic properties, but worsens cognitive abilities, causes a decrease in the number of movements between sleep stages, at a dosage of 0.5 mg of bretazenil, REM sleep is reduced, and stage 2 of sleep is lengthened.
This drug has never been commercialized and is sold only as a research substance, a designer drug.
You can buy Bretazenil online at teamchemists.com
Product information
IUPAC-name (13aS)-8-
Synonyms Bretazenil, Ro 16-6028
Formal name 1-(8-chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)-N,N-dimethylmethanamine
Cas number 84379-13-5
Formula C19H20BrN3O3
Molar Mass 418.3
Formulation Crystalline Solid, Powder
Purity 98.0 % min.
Appearance A crystalline solid, Powder
Solubility
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- Ethanol: 20 mg/ml
- PBS (pH 7.2): Partially soluble
Shipping & Storage Information
Storage -20°C
Shipping Room Temperature in continental US; vary elsewhere
Stability ≥ 2 years
WARNING This product is not for human or veterinary use.
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